San Francisco sits at 3-0 but the Nick Bosa injury introduces a cascade of adjustments. The 49ers must compensate with interior pressure, more blitzes, and greater load on Bryce Huff and a rising rookie corps. Offensively, reinforcements—Brandon Aiyuk, Ricky Pearsall, Demarcus Robinson—should lift a run- and pass-blocking-challenged unit, while the defense retools around creative schemes. The NFC remains open and in-season moves loom as teams gauge the market.

Nick Bosa ACL tear against the Cardinals upends SFs defense and forces a swift pivot to next-man-up behind a veteran staff led by Robert Saleh.

Seattle rides a hot start and dominant special teams to the top of the division, while the Rams stumble late in a big win probability swing that raises questions about Stafford health and the offense’s reliance on Puka Nacua. Arizona shows offensive struggles and Kyler Murrays volatility, as Lynch circles for big edge help. Trade chatter heats as Hendrickson and Thibodeaux enter the rumor mill ahead of a pivotal Week 4 slate that features SF-Jaguars, Rams-Colts, and Seahawks-Cardinals.

Parsons to Green Bay for two first-round picks and Kenny Clark reshapes the NFL edge and interior game in one marquee swap. Green Bay pays Parsons like a unicorn non-QB, boosting their immediate title odds while elevating the front seven’s ceiling. New England debates the price as a pivot point for its own arc, and the buzz ripples through fantasy as GB’s sack and tackle floors look to jump with Parsons patrolling the edge next to Clark.